Abstract
In order to examine the circulatory and bronchospasmolytic activity, new 7-beta-hydroxy-gamma-N4-alkylpiperazinopropyl-8- benzylaminotheophyllines (1, 2, 3) were synthesized and converted to the water soluble dihydrochlorides (1a, 2a, 3a). They showed hypotensive and bronchodilatory effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antihypertensive Agents / chemical synthesis*
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Blood Pressure / drug effects
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Bronchodilator Agents / chemical synthesis*
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Cats
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Chemical Phenomena
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Chemistry
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Electrocardiography
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Female
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Guinea Pigs
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In Vitro Techniques
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Myocardial Contraction / drug effects
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Piperazines / chemical synthesis*
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Piperazines / pharmacology
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Rabbits
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Rats
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Rats, Inbred Strains
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Respiration / drug effects
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Theophylline / analogs & derivatives*
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Theophylline / chemical synthesis
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Theophylline / pharmacology
Substances
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Antihypertensive Agents
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Bronchodilator Agents
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Piperazines
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Theophylline