[Stem cell therapy in diabetes: a promising future]

Y P Wang; L Zang; Y M Mu

doi:10.3760/cma.j.cn112138-20230626-00332

[Stem cell therapy in diabetes: a promising future]

Zhonghua Nei Ke Za Zhi. 2023 Sep 1;62(9):1039-1042. doi: 10.3760/cma.j.cn112138-20230626-00332.

[Article in Chinese]

Authors

Y P Wang¹, L Zang², Y M Mu²

Affiliations

¹ Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China School of Medicine, Nankai University, Tianjin 300071, China.
² Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

PMID: 37650175
DOI: 10.3760/cma.j.cn112138-20230626-00332

Abstract

干细胞以其自我更新和多向分化的生物学优势，通过免疫调节功能、组织修复功能及分化功能，在糖尿病的治疗中展现出良好的应用前景。间充质干细胞移植对1型和2型糖尿病患者有一定疗效，但临床结果不能令人满意，需要提高间充质干细胞体内存活时间及疗效。干细胞诱导分化的胰岛素分泌细胞为胰岛衰竭型糖尿病的治疗提供了理想的胰岛细胞补充来源，但免疫排斥及安全性问题仍是干细胞诱导分化的胰岛素分泌细胞应用中面临的主要问题，尚需开展临床研究探索其有效性及安全性。.

MeSH terms

Cell- and Tissue-Based Therapy
Diabetes Mellitus* / therapy
Humans