Overcoming Barriers to Autologous Stem Cell Transplantation in Multiple Myeloma: Recommendations from a Multidisciplinary Roundtable Discussion

Transplant Cell Ther. 2023 Nov;29(11):666-673. doi: 10.1016/j.jtct.2023.08.028. Epub 2023 Sep 1.

Abstract

Autologous stem cell transplantation (ASCT) is a standard of care treatment for patients with multiple myeloma (MM). However, only 20% to 30% of patients with MM for whom the procedure is indicated undergo ASCT. Barriers to ASCT may be informational, financial, logistic, or cultural and may affect patients and treating oncologists. Available and accessible accurate ASCT-related information is essential to overcome these barriers. Such resources can be created by blood and marrow transplantation societies and patient advocacy groups, ideally in collaboration with MM specialists at transplant centers. An umbrella office at the society level is also recommended to connect oncologists, advocacy groups, and transplantation specialists; provide informational resources to patients; and conduct research into region- and population-specific barriers to ASCT.

Keywords: Autologous transplantation; Barriers to treatment; Clinical decision making; Multiple myeloma.

Publication types

  • Review

MeSH terms

  • Hematopoietic Stem Cell Transplantation* / methods
  • Humans
  • Multiple Myeloma* / therapy
  • Transplantation, Autologous / methods
  • Treatment Outcome