A Review on Inflammasomes and Immune Checkpoints in Pre-Eclampsia Complicated with Tuberculosis and Human Immune Deficiency Virus

Int J Environ Res Public Health. 2023 Aug 22;20(17):6627. doi: 10.3390/ijerph20176627.

Abstract

The current review evaluates how inflammasomes and immune checkpoints are regulated in pre-eclampsia (PE) associated with tuberculosis (TB) and Human Immune Deficiency Virus (HIV). Studies indicate that inflammasomes such as (NRLP3, NEK7, and AIM2) and immune checkpoints such as (CLT4, PD-1, TIM3, and LAG-3) are dysregulated in TB- and HIV-infected individuals, and also in pre-eclamptic pregnancies, which explains why pregnant women who are either infected with TB or HIV have an increased risk of developing PE. Evidence suggests that inhibition of inflammasomes and immune checkpoints may assist in the development of novel anti-inflammatory drugs for the prevention and management of PE in patients with or without TB and HIV infection.

Keywords: HIV; immune check points; inflammasomes; inflammation; pre-eclampsia; tuberculosis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • HIV Infections* / complications
  • Humans
  • Inflammasomes
  • Inhibition, Psychological
  • Pre-Eclampsia*
  • Pregnancy
  • Tuberculosis*

Substances

  • Inflammasomes

Grants and funding

This study is part of a bigger study that is funded by the National Research Foundation (NRF), Opinions expressed, and conclusions arrived at, are those of the author and not necessarily to be attributed to the NRF (South Africa, grant number: 138389).