Convergent insights into intratumor heterogeneity

Claudia Manini; Annick Laruelle; André Rocha; José I López

doi:10.1016/j.trecan.2023.08.009

Convergent insights into intratumor heterogeneity

Trends Cancer. 2024 Jan;10(1):12-14. doi: 10.1016/j.trecan.2023.08.009. Epub 2023 Sep 6.

Authors

Claudia Manini¹, Annick Laruelle², André Rocha³, José I López⁴

Affiliations

¹ Department of Pathology, San Giovanni Bosco Hospital, 10154 Turin, Italy; Department of Sciences of Public Health and Pediatrics, University of Turin, 10124 Turin, Italy.
² Department of Economic Analysis, University of the Basque Country (UPV/EHU), 48015 Bilbao, Spain; IKERBASQUE, Basque Foundation of Science, 48011 Bilbao, Spain.
³ Department of Industrial Engineering, Pontifical Catholic University of Rio de Janeiro, CEP22451-900 Rio de Janeiro, Brazil.
⁴ Biomarkers in Cancer, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain. Electronic address: joseignacio.lopez@biocrucesbizkaia.org.

PMID: 37684129
DOI: 10.1016/j.trecan.2023.08.009

Abstract

Mathematics, conventional histology, and genomics converge to confirm that highly aggressive clear cell renal cell carcinomas (CCRCCs) display low levels of intratumor heterogeneity (ITH). We hypothesize that therapeutic strategies aimed at maintaining high ITH levels would be advisable to slow down cancer evolution and to improve survival.

Keywords: game theory; genomics; histopathology; intratumor heterogeneity.

MeSH terms

Carcinoma, Renal Cell* / genetics
Carcinoma, Renal Cell* / pathology
Genomics
Humans
Kidney Neoplasms* / genetics
Kidney Neoplasms* / pathology

Abstract

MeSH terms

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