Prevalence, Incidence, and Predictors of Kaposi Sarcoma-Associated Herpesvirus Infection Among Young Men Who Have Sex With Men in the Southern United States

J Infect Dis. 2024 May 15;229(5):1387-1392. doi: 10.1093/infdis/jiad384.

Abstract

Kaposi sarcoma (KS) continues to cause substantial morbidity and mortality in populations at risk in the southern United States. Utilizing biospecimens from the Houston site of the Young Men's Affiliate Project, 351 men who have sex with men had blood tested for KS-associated herpesvirus (KSHV) IgG. Seroprevalence, seroconversion between time points, and demographic and clinical correlates were measured. KSHV prevalence was 36.7% and incidence was 8.9 per 100 person-years. Furthermore, prevalence and incidence were higher among Black individuals, people living with HIV, and those with a history of syphilis. Further research on KSHV risk may improve health disparities in KS diagnosis and outcomes.

Keywords: HIV; Kaposi sarcoma; human herpesvirus 8; racial disparities; seroprevalence.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood
  • HIV Infections / epidemiology
  • Herpesviridae Infections / epidemiology
  • Herpesvirus 8, Human* / immunology
  • Homosexuality, Male*
  • Humans
  • Incidence
  • Male
  • Prevalence
  • Risk Factors
  • Sarcoma, Kaposi* / epidemiology
  • Sarcoma, Kaposi* / virology
  • Seroepidemiologic Studies
  • Syphilis / epidemiology
  • United States / epidemiology
  • Young Adult