Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes

Org Lett. 2023 Sep 29;25(38):7030-7034. doi: 10.1021/acs.orglett.3c02615. Epub 2023 Sep 15.

Abstract

An efficient method for generating 3-triazenylarynes from ortho-iodoaryl triflate-type precursors was developed. The generated arynes reacted with various arynophiles with high regioselectivity because of the triazenyl group. The 3-triazenylaryne precursors functioned as useful intermediates of diverse multisubstituted aromatic compounds through the transformation of the remaining triazenyl group of aryne adducts and triazenyl group-directed ortho-C-H functionalization.