Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis

Maisam Abu-El-Haija; Lindsey Hornung; Kate Ellery; Douglas S Fishman; Tanja Y Gonska; Cheryl Gariepy; Mark Lowe; Katie Larson Ode; Asim Maqbool; Maria Mascarenhas; Veronique D Morinville; Chee Y Ooi; Emily R Perito; Sarah Jane Schwarzenberg; Zachary M Sellers; Babette S Zemel; Ying Yuan; Fuchenchu Wang; Aliye Uc; Heidi J Kalkwarf; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

doi:10.1016/j.pan.2023.08.006

Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis

Pancreatology. 2023 Nov;23(7):755-760. doi: 10.1016/j.pan.2023.08.006. Epub 2023 Aug 31.

Authors

Maisam Abu-El-Haija¹, Lindsey Hornung², Kate Ellery³, Douglas S Fishman⁴, Tanja Y Gonska⁵, Cheryl Gariepy⁶, Mark Lowe⁷, Katie Larson Ode⁸, Asim Maqbool⁹, Maria Mascarenhas⁹, Veronique D Morinville¹⁰, Chee Y Ooi¹¹, Emily R Perito¹², Sarah Jane Schwarzenberg¹³, Zachary M Sellers¹⁴, Babette S Zemel⁹, Ying Yuan¹⁵, Fuchenchu Wang¹⁵, Aliye Uc¹⁶, Heidi J Kalkwarf¹⁷; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Affiliations

¹ Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: maisam.haija@cchmc.org.
² Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
³ Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
⁴ Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
⁵ Hospital for Sick Children, Toronto, ON, Canada.
⁶ Nationwide Children's Hospital, Columbus, OH, USA.
⁷ Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA.
⁸ Department of Pediatrics, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA.
⁹ Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
¹⁰ Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
¹¹ Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales and Department of Gastroenterology, Sydney Children's Hospital Randwick, Sydney, Australia.
¹² University of California San Francisco, San Francisco, CA, USA.
¹³ University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
¹⁴ Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stanford University, Palo Alto, CA, USA.
¹⁵ Department of Biostatistics, University of Texas MD, Anderson Cancer Center, Huston, TX, USA.
¹⁶ Department of Pediatrics, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA; Radiation Oncology, University of Iowa, Iowa City, IA, USA.
¹⁷ Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Abstract

Background/objectives: Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied.

Methods: This retrospective study was performed at three sites and included data from INSPPIRE-2.

Results: Of the 87 children in the study: 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < -2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < -2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively).

Conclusion: Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.

Keywords: Bone health; Children; Pancreatitis.

Publication types

Multicenter Study

MeSH terms

Adolescent
Bone Density*
Child
Cross-Sectional Studies
Humans
Pancreatitis, Chronic* / complications
Pancreatitis, Chronic* / epidemiology
Retrospective Studies

Abstract

Publication types

MeSH terms

Grants and funding