Sinonasal phosphaturic mesenchymal tumour: radiation oncologist's perspective

BMJ Case Rep. 2023 Sep 18;16(9):e255896. doi: 10.1136/bcr-2023-255896.

Abstract

Tumour-induced osteomalacia is a rare cause of osteomalacia, the majority of which is of mesenchymal origin. Oncogenic osteomalacia is a potentially curable condition caused by phosphaturic mesenchymal tumours. We present the case of a woman in her 30s with a sinonasal phosphaturic mesenchymal tumour, treated with surgical excision followed by adjuvant intensity-modulated radiotherapy and subsequent adjuvant chemotherapy. The patient experienced minimal adverse effects during radiation. There was good local control and cosmetic outcomes with no radiation-related toxicity at a follow-up period of 32 months.

Keywords: Calcium and bone; Head and neck cancer; Radiotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Immunologic
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Mesenchymoma* / complications
  • Mesenchymoma* / radiotherapy
  • Mesenchymoma* / surgery
  • Osteomalacia
  • Paraneoplastic Syndromes
  • Radiation Injuries*
  • Radiation Oncologists
  • Soft Tissue Neoplasms*

Substances

  • Adjuvants, Immunologic

Supplementary concepts

  • Oncogenic osteomalacia