Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Caused by Itraconazole in a 17-Year-Old Girl

Pediatr Allergy Immunol Pulmonol. 2023 Dec;36(4):143-146. doi: 10.1089/ped.2023.0066. Epub 2023 Sep 20.

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe adverse drug-induced hypersensitivity reaction. We report a case of DRESS syndrome in a 17-year-old female caused by itraconazole, confirmed by patch testing, that required treatment with both corticotherapy and cyclosporine. Our case highlights the importance of clinical suspicion of this syndrome in pediatric age and the novelty of an antifungal drug being identified as the culprit.

Keywords: DRESS syndrome; itraconazole; myositis; patch testing.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child
  • Cyclosporine / adverse effects
  • Drug Hypersensitivity Syndrome* / diagnosis
  • Drug Hypersensitivity Syndrome* / drug therapy
  • Drug Hypersensitivity Syndrome* / etiology
  • Eosinophilia* / chemically induced
  • Eosinophilia* / diagnosis
  • Exanthema* / chemically induced
  • Exanthema* / diagnosis
  • Female
  • Humans
  • Itraconazole / adverse effects

Substances

  • Itraconazole
  • Cyclosporine