The AD odyssey 2023: Tales of single cell

Wenjie Luo; Wenhui Qu; Li Gan

doi:10.1016/j.cell.2023.09.001

The AD odyssey 2023: Tales of single cell

Cell. 2023 Sep 28;186(20):4257-4259. doi: 10.1016/j.cell.2023.09.001.

Authors

Wenjie Luo¹, Wenhui Qu¹, Li Gan²

Affiliations

¹ Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
² Helen and Robert Appel Alzheimer's Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. Electronic address: lig2033@med.cornell.edu.

PMID: 37774675
DOI: 10.1016/j.cell.2023.09.001

Abstract

Deciphering cellular changes in Alzheimer's disease (AD) using large cohorts with defined clinical stages is essential for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies harnessed the power of single-nuclei RNA sequencing (snRNA-seq) and single-nuclei ATAC sequencing (snATAC-seq) at unprecedented scale and revealed exciting insights into cell-type-specific mechanisms underlying the progression of AD pathogenesis.

Publication types

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MeSH terms

Alzheimer Disease* / genetics
Alzheimer Disease* / pathology
Humans
RNA, Small Nuclear
Sequence Analysis, RNA

Substances

RNA, Small Nuclear