Anxiolytics cause anxiety in pancreatic cancer

Trends Cancer. 2023 Nov;9(11):874-875. doi: 10.1016/j.trecan.2023.09.005. Epub 2023 Sep 29.

Abstract

Benzodiazepines (BZDs) are commonly prescribed for pancreatic cancer patients. To investigate the correlation between BZDs and survival outcomes a recent study by Cornwell et al. found that lorazepam (LOR) correlates with poor survival. The mechanistic study shows that LOR increases interleukin 6 (IL6) expression in cancer-associated fibroblasts via GPR68.

Keywords: GPR68; benzodiazepines; fibroblast; interleukin 6; pancreatic cancer; survival.

Publication types

  • Comment

MeSH terms

  • Anti-Anxiety Agents* / adverse effects
  • Anxiety / etiology
  • Benzodiazepines / adverse effects
  • Humans
  • Lorazepam
  • Pancreatic Neoplasms* / drug therapy
  • Receptors, G-Protein-Coupled

Substances

  • Anti-Anxiety Agents
  • Benzodiazepines
  • Lorazepam
  • GPR68 protein, human
  • Receptors, G-Protein-Coupled