Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report

Lindsay Wilson; Ju-Wei Chang; Stuart Meier; Tariq Ganief; Naadir Ganief; Suzette Oelofse; Vicky Baillie; Marta C Nunes; Shabir A Madhi; Jonathan Blackburn; Keertan Dheda

doi:10.1093/ofid/ofad451

Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report

Open Forum Infect Dis. 2023 Aug 31;10(10):ofad451. doi: 10.1093/ofid/ofad451. eCollection 2023 Oct.

Authors

Lindsay Wilson¹, Ju-Wei Chang¹, Stuart Meier¹, Tariq Ganief^{2

3}, Naadir Ganief^{2

3}, Suzette Oelofse¹, Vicky Baillie^{4

5}, Marta C Nunes^{4

5}, Shabir A Madhi^{4

5

6}, Jonathan Blackburn^{2

3}, Keertan Dheda^{1

7}

Affiliations

¹ Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute & South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa.
² Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
³ Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
⁴ South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁵ Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁶ African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁷ Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK.

Abstract

The pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia remains poorly understood. The urine proteome of hospitalized patients with severe COVID-19 pneumonia, compared with severe non-COVID-19 pneumonia controls, was distinct and associated with lower abundance of several host proteins. Protein-specific machine learning analysis outlined biomarker combinations able to differentiate COVID-19 pneumonia from non-COVID-19 pneumonia controls.

Keywords: hospitalized; pathogenesis; pneumonia.