[Two Cases of Catheter-Related Venous Thrombosis Treated with Direct Oral Anticoagulants(DOAC)]

Gan To Kagaku Ryoho. 2023 Sep;50(9):993-996.
[Article in Japanese]

Abstract

The implantation of a totally implantable central venous(CV)access port is considered a risk factor for venous thromboembolism( VTE). In the treatment of catheter-related thrombosis(CRT), both European and American guidelines recommend anticoagulation therapy with catheters in place. We experienced 2 cases of upper extremity deep vein thrombosis (UEDVT)after the implantation of CV access ports through the left subclavian vein for adjuvant chemotherapy in patients with resected breast cancer. Both patients were successfully treated with direct oral anticoagulants(DOAC) while the port remained in place with a careful follow-up that included monitoring of serum D-dimer levels. The administration of DOAC to CRT that develops in patients undergoing postoperative adjuvant chemotherapy for breast cancer may be relatively safe, with a low potential for adverse events such as bleeding.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anticoagulants / adverse effects
  • Breast Neoplasms* / drug therapy
  • Central Venous Catheters* / adverse effects
  • Female
  • Humans
  • Upper Extremity Deep Vein Thrombosis* / drug therapy
  • Upper Extremity Deep Vein Thrombosis* / etiology
  • Venous Thromboembolism* / drug therapy
  • Venous Thrombosis* / drug therapy
  • Venous Thrombosis* / etiology

Substances

  • Anticoagulants