Fishing for "complements" with vascular organoid models of microvascular disease

Sean X Gu; Timur O Yarovinsky; John Hwa

doi:10.1016/j.stem.2023.09.004

Fishing for "complements" with vascular organoid models of microvascular disease

Cell Stem Cell. 2023 Oct 5;30(10):1285-1286. doi: 10.1016/j.stem.2023.09.004.

Authors

Sean X Gu¹, Timur O Yarovinsky², John Hwa³

Affiliations

¹ Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
² Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
³ Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Yale Cooperative Center of Excellence in Hematology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: john.hwa@yale.edu.

PMID: 37802032
DOI: 10.1016/j.stem.2023.09.004

Abstract

In this issue of Cell Stem Cell, Kawakami et al. develop a SARS-CoV-2 infection-competent, progenitor-derived, human vascular organoid model and uncover a role for complement factor D (CFD) in mediating microvascular immunothrombosis. This model may be applied to conditions where microvascular disease plays a major pathogenic role.

MeSH terms

COVID-19*
Humans
Organoids