[Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine]

Farmaco Sci. 1986 Sep;41(9):713-21.
[Article in Italian]

Abstract

Some 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylendiamines were synthetized and tested against lymphocytic murine leukemia P 388. Compounds (I)-(III), (VIII)-(XII) and (XVIII)-(XIX) showed significant by prolongation the survival time of tumor-bearing mice (T/C% 129-194).

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Chemical Phenomena
  • Chemistry
  • Diamines / chemical synthesis*
  • Diamines / pharmacology
  • Leukemia P388 / drug therapy*
  • Leukemia, Experimental / drug therapy*
  • Mice
  • Thiadiazoles / chemical synthesis*
  • Thiadiazoles / pharmacology

Substances

  • Antineoplastic Agents
  • Diamines
  • Thiadiazoles