Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis

Abstract

Objective: Our meta-analysis aims to explore the association of two single nucleotide variants; rs9939609 and rs8050136, within the FTO gene with risk of pulmonary tuberculosis (PTB).

Methods: The association of two single nucleotide variants with PTB in three genetic models was evaluated using pooled odds ratios (ORs) with 95% CIs.

Results: No significant association was observed between the rs9939609 polymorphism and PTB when assuming an allelic model (OR: 1.10; 95% CI: 0.85-1.41; P=0.47; I² = 64.98%), a recessive model (OR: 2.04; 95% CI: 0.87-4.77; P=0.10; I² = 67.18%), or a dominant model (OR: 0.96; 95% CI: 0.83-1.11; P=0.56; I² = 27.45%). Likewise, no association was observed between rs8050136 polymorphism and PTB when assuming allelic model (OR: 1.17; 95% CI: 0.87-1.58; P=0.31; I² = 64.20%) or recessive model (OR: 1.04; 95% CI: 0.32-3.38; P=0.95; I² = 68.82%) or dominant model (OR: 1.22; 95% CI: 0.87-1.71; P=0.26; I² = 58.69%).

Conclusion: There might be no association between the rs9939609 and rs8050136 variants in the FTO gene, and the risk of PTB.

Keywords: FTO gene; polymorphism; rs8050136; rs9939609; single nucleotide variant; tuberculosis.