Pearls & Oy-sters: Leber Hereditary Optic Neuropathy-Plus Masquerading as Neuromyelitis Optica Spectrum Disorder in a 2-Year-Old Child

Alex Sunshine; Quinton J Mandle; Ana M Cabal Herrera; Bianca Zapanta; Hersh Varma; Setty Magaña

doi:10.1212/WNL.0000000000207979

Pearls & Oy-sters: Leber Hereditary Optic Neuropathy-Plus Masquerading as Neuromyelitis Optica Spectrum Disorder in a 2-Year-Old Child

Neurology. 2023 Dec 12;101(24):e2585-e2588. doi: 10.1212/WNL.0000000000207979. Epub 2023 Oct 12.

Authors

Alex Sunshine¹, Quinton J Mandle¹, Ana M Cabal Herrera¹, Bianca Zapanta¹, Hersh Varma¹, Setty Magaña¹

Affiliation

¹ From the Neurology (A.S., Q.J.M., S.M.); Pediatrics (A.M.C.H.); Genetics (B.Z.); and Ophthalmology (H.V.), Nationwide Children's Hospital.

Abstract

"Leber hereditary optic neuropathy (LHON-Plus)" is a phenotype of LHON that is characterized by extraocular neurologic manifestations, which may be the first manifestations of the disease.

Publication types

Case Reports

MeSH terms

Child, Preschool
Humans
Neuromyelitis Optica* / diagnosis
Optic Atrophy, Hereditary, Leber* / diagnosis
Optic Atrophy, Hereditary, Leber* / genetics