Factors influencing in vitro sieving of blood in cerebrovascular accidents. Clinical significance and therapeutic strategy

Klin Wochenschr. 1986 Oct 15;64(20):1053-7.

Abstract

A haemorheological analysis with measured blood filterability was carried out on 179 patients with cerebrovascular accidents. Reduced blood filterability appeared to be related to the clinical condition: time variation (two phase course), influence of complications and of fatal prognosis. The underlying mechanism of the haemorheological disorders involved three groups of factors: quantitative and qualitative abnormalities of plasma proteins, red cells disturbances and white cells activation, leading to both local and general hyperviscosity, producing a prothrombotic state and a defective microcirculation. The haemorheological treatments are of value to the patients although the relationship between hemodilution and the filterability remains to be exactly defined, as well as a better understanding of the action of the drugs.

MeSH terms

  • Blood
  • Blood Viscosity*
  • Cerebrovascular Circulation
  • Erythrocyte Aggregation / blood
  • Hematocrit*
  • Hemodilution
  • Humans
  • Intracranial Arteriosclerosis / blood
  • Intracranial Embolism and Thrombosis / blood*
  • Intracranial Embolism and Thrombosis / therapy
  • Rheology*
  • Risk
  • Ultrafiltration