LINC00667: A Novel Vital Oncogenic LincRNA

Yaqi Hu; Yifan Zhang; Shuwen Wang; Rui Wang; Qi Yuan; Leiqi Zhu; Fangqi Xia; Mengzhen Xue; Yaqi Wang; Yuanyang Li; Chengfu Yuan

doi:10.2174/0109298673248494231010044348

LINC00667: A Novel Vital Oncogenic LincRNA

Curr Med Chem. 2023 Oct 19. doi: 10.2174/0109298673248494231010044348. Online ahead of print.

Authors

Yaqi Hu^{1

2}, Yifan Zhang^{1

2}, Shuwen Wang^{1

2}, Rui Wang^{1

2}, Qi Yuan¹, Leiqi Zhu^{1

2}, Fangqi Xia^{1

2}, Mengzhen Xue^{1

2}, Yaqi Wang^{1

2}, Yuanyang Li¹, Chengfu Yuan^{1

2}

Affiliations

¹ Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China.
² College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.

PMID: 37855347
DOI: 10.2174/0109298673248494231010044348

Abstract

Long intergenic noncoding RNAs (lincRNAs) have a variety of properties that differ from those of messenger RNAs (mRNAs) encoding proteins. Long intergenic nonprotein coding RNA 667 (LINC00667) is a non-coding transcript located on chromosome 18p11.31. Recently, many studies have found that LINC00667 can enhance the progression of various cancers and play a key part in a lot of diseases, such as tumorigenesis. Therefore, LINC00667 can be recognized as a potential biomarker and therapeutic target. So, we reviewed the biological functions, relevant mechanisms, as well as clinical significance of LINC00667 in several human cancers in detail.

Keywords: LINC00667; cancers; cell functions; long intergenic noncoding RNAs (lincRNAs).