Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?

Shengxu Zhu; Junlin Wang; Moran Suo; Huagui Huang; Xin Liu; Jinzuo Wang; Zhonghai Li

doi:10.1016/j.arr.2023.102094

Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?

Ageing Res Rev. 2023 Dec:92:102094. doi: 10.1016/j.arr.2023.102094. Epub 2023 Oct 18.

Authors

Shengxu Zhu¹, Junlin Wang², Moran Suo¹, Huagui Huang¹, Xin Liu¹, Jinzuo Wang¹, Zhonghai Li³

Affiliations

¹ Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, the People's Republic of China; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Liaoning Province, the People's Republic of China.
² Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, the People's Republic of China.
³ Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, the People's Republic of China; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Liaoning Province, the People's Republic of China. Electronic address: lizhonghaispine@126.com.

PMID: 37863436
DOI: 10.1016/j.arr.2023.102094

Abstract

As a global public health problem, low back pain (LBP) caused by intervertebral disc degeneration (IDD) seriously affects patients' quality of life. In addition, the prevalence of IDD tends to be younger, which brings a huge burden to individuals and society economically. Current treatments do not delay or reverse the progression of IDD. The emergence of biologic therapies has brought new hope for the treatment of IDD. Among them, extracellular vesicles (EVs), as nanoscale bioactive substances that mediate cellular communication, have now produced many surprising results in the research of the treatment of IDD. This article reviews the mechanisms and roles of EVs in delaying IDD and describes the prospects and challenges of EVs.

Keywords: Biological therapy; Extracellular vesicles; Intervertebral disc degeneration; Mechanism.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Extracellular Vesicles*
Humans
Intervertebral Disc Degeneration* / therapy
Intervertebral Disc Displacement*
Quality of Life

Supplementary concepts

Intervertebral disc disease