Epigenetics and recurrent urinary tract infections: an update on current research and potential clinical application

Ghazal Aghagoli; Alexey V Fedulov; Julia K Shinnick

doi:10.2217/epi-2023-0311

Epigenetics and recurrent urinary tract infections: an update on current research and potential clinical application

Epigenomics. 2023 Oct;15(19):961-964. doi: 10.2217/epi-2023-0311. Epub 2023 Oct 31.

Authors

Ghazal Aghagoli^{1

2}, Alexey V Fedulov^{1

3}, Julia K Shinnick^{1

2}

Affiliations

¹ The Warren Alpert Medical School of Brown University, Providence, RI 02912, USA.
² Department of Urogynecology & Reconstructive Pelvic Surgery, Women & Infants Hospital, Providence, RI 02903, USA.
³ Department of Surgery, Rhode Island Hospital, Providence, RI 02903, USA.

PMID: 37905413
DOI: 10.2217/epi-2023-0311

Abstract

Tweetable abstract Exploring uropathogenic E. coli-induced epigenetic changes in uroepithelial cells contributing to recurrent UTIs and potential therapeutic strategies. Understanding these mechanisms could inform novel UTI interventions.

Keywords: epigenetic mechanisms; recurrent UTIs; urinary tract infection; uropathogenic E. coli; urothelial cells.

Publication types

Editorial

MeSH terms

Epigenesis, Genetic
Epigenomics
Escherichia coli Infections* / drug therapy
Humans
Urinary Tract Infections* / drug therapy
Urinary Tract Infections* / genetics
Uropathogenic Escherichia coli* / genetics