LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways

Shadia Hamoud Alshahrani; Zeina S M Al-Hadeithi; Sami G Almalki; Jitendra Malviya; Ahmed Hjazi; Yasser Fakri Mustafa; Ahmed Hussien Radie Alawady; Ali Hashiem Alsaalamy; S K Joshi; Adnan Taan Alkhafaji

doi:10.1016/j.prp.2023.154898

LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways

Pathol Res Pract. 2023 Nov:251:154898. doi: 10.1016/j.prp.2023.154898. Epub 2023 Oct 16.

Affiliations

¹ Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.
² College of Pharmacy, Al-Nahrain University, Kadhimiya, Baghdad, Iraq.
³ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia. Electronic address: sg.almalki@mu.edu.sa.
⁴ Department of Life Sciences and Biological Sciences, IES University Bhopal, Madhya Pradesh, India.
⁵ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
⁶ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq.
⁷ College of Technical Engineering, the Islamic University, Najaf, Iraq; College of Technical Engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; College of Technical Engineering, the Islamic University of Babylon, Babylon, Iraq.
⁸ College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna 66002, Iraq.
⁹ Mechanical Engineering Department, Uttaranchal Institute of Technology, Uttaranchal University, Dehradun 248007, India.
¹⁰ Cardiology Department, College of Medicine, Al-Ayen University, Thi-Qar, Iraq.

PMID: 37924797
DOI: 10.1016/j.prp.2023.154898

Abstract

LncRNAs function as molecular sponges for miRNAs to control their availability for targeting mRNA molecules. This procedure indirectly regulates the expression of cancer-related genes. Some lncRNAs also directly interact with miRNAs, leading to their degradation or sequestration, which can negatively impact gene expression. miRNAs, on the other hand, play a critical role in controlling the expression of genes, including oncogenes and tumor suppressor genes. Multiple types of cancer have been linked to the onset and progression of miRNA dysregulation. Even though there is a lot of potential for treating CRC by targeting the LncRNA-miRNA axis, several challenges remain to be overcome. The specificity of the targeting approach, delivery methods, resistance, safety, and cost-effectiveness are critical research areas that must be addressed to advance this field and improve treatment outcomes for people with CRC.

Keywords: Colorectal cancer; LncRNA; MiRNA; Signaling.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / pathology
Gene Expression Regulation, Neoplastic / genetics
Gene Regulatory Networks
Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
Oncogenes
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Signal Transduction / genetics

Substances

MicroRNAs
RNA, Long Noncoding