MXene-enhanced ePatch with antibacterial activity for wound healing

Jing Feng; Rui Liu; Xuefeng Yuan; Changkui Cao; Ji Xie; Zhaorui Sun; Sai Ma; Shinan Nie

doi:10.3389/fchem.2023.1280040

MXene-enhanced ePatch with antibacterial activity for wound healing

Front Chem. 2023 Oct 19:11:1280040. doi: 10.3389/fchem.2023.1280040. eCollection 2023.

Authors

Jing Feng^{1

2}, Rui Liu^{1

2}, Xuefeng Yuan^{1

2}, Changkui Cao^{1

2}, Ji Xie^{1

2}, Zhaorui Sun^{1

2}, Sai Ma^{3

4}, Shinan Nie^{1

2}

Affiliations

¹ Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
² Department of Emergency Medicine, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.
³ Department of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
⁴ Department of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.

Abstract

Prudent wound-healing strategies hold great potential in expediting tissue renovation and regeneration. Despite the widespread adoption of hydrogels as preferred carriers for wound healing patches, achieving optimal mechanical compatibility and superior wound performance remains a formidable challenge. Consequently, meticulous attention must be given to the formulation of hydrogel structure and materials design to overcome these hurdles. In response, we have developed an ePatch composed of polyacrylamide (PAAM) as the primary hydrogel structure, augmented with MXene, silver nanowires (AgNWs), and resveratrol to act as sustained-release agents, structural enhancers, and antibacterial agents, respectively. Notably, the ePatch exhibited exceptional wound-fitting capabilities and impressive mechanical stretchability (with a relative standard deviation [RSD] of only 1.36% after 55 stretches) and Young's modulus. In contrast to the commercial 3M Tegaderm, the ePatch demonstrated superior wound healing properties, with the inclusion of MXene into PAAM/AgNWs playing a pivotal role in expanding the ePatch's potential use across various interconnected fields.

Keywords: MXene; ePatch; enhanced; hydrogel; wound healing.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was financially supported by the PLA Youth Training Project for Medical Science (19QNP037), the National Natural Science Foundation of China (81900409, 82172182), and the Natural Science Foundation of Jiangsu Province (BK20211136).