Commentary: Commentary: Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Michelle D van den Beukel; Anna E C Stoelinga; Adriaan J van der Meer; Stef van der Meulen; Lu Zhang; Maarten E Tushuizen; Bart van Hoek; Leendert A Trouw

doi:10.3389/fmed.2023.1297191

Commentary: Commentary: Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Front Med (Lausanne). 2023 Oct 23:10:1297191. doi: 10.3389/fmed.2023.1297191. eCollection 2023.

Authors

Michelle D van den Beukel^#¹, Anna E C Stoelinga^#², Adriaan J van der Meer³, Stef van der Meulen¹, Lu Zhang¹, Maarten E Tushuizen², Bart van Hoek², Leendert A Trouw¹

Affiliations

¹ Department of Immunology, Leiden University Medical Center, Leiden, Netherlands.
² Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands.
³ Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands.

^# Contributed equally.

No abstract available

Keywords: AIH—autoimmune hepatitis; BSA; FCS—fetal calf serum; PTM—post-translational modification; anti-CarP; antibodies against carbamylated proteins; pIgG—polyreactive IgG.

Publication types

Comment

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. MB, SM, LZ, and LT have received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement no. 724517). AS, MT, and BH received a ZonMW grant (nr 10140022010001) and funding from Chiesi Pharmaceuticals B.V. (project number: PA 2019-71111) for a different project on the topic of autoimmune hepatitis.