Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

Brandilyn A Peters; Adam Whalen; Xiaonan Xue; Elizabeth F Topper; Kathleen M Weber; Phyllis C Tien; Seble G Kassaye; Howard Minkoff; Ervin Fox; Margaret A Fischl; Lauren F Collins; Michelle Floris-Moore; Howard N Hodis; Qibin Qi; David B Hanna; Anjali Sharma; Kathryn Anastos; Robert C Kaplan

doi:10.1093/infdis/jiad488

Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

J Infect Dis. 2024 Mar 14;229(3):780-785. doi: 10.1093/infdis/jiad488.

Authors

Brandilyn A Peters¹, Adam Whalen¹, Xiaonan Xue¹, Elizabeth F Topper², Kathleen M Weber³, Phyllis C Tien^{4

5}, Seble G Kassaye⁶, Howard Minkoff⁷, Ervin Fox⁸, Margaret A Fischl⁹, Lauren F Collins¹⁰, Michelle Floris-Moore¹¹, Howard N Hodis¹², Qibin Qi¹, David B Hanna¹, Anjali Sharma¹³, Kathryn Anastos¹³, Robert C Kaplan^{1

14}

Affiliations

¹ Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
² Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
³ CORE Center of Cook County Health and Hospital System/Hektoen Institute of Medicine, Chicago, Illinois, USA.
⁴ Division of Infectious Diseases, University of California San Francisco, San Francisco, California, USA.
⁵ Medical Service, Department of Veterans Affairs, San Francisco, California, USA.
⁶ Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia, USA.
⁷ Department of Obstetrics and Gynecology, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
⁸ Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
⁹ Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
¹⁰ Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
¹¹ Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
¹² Departments of Medicine and Population and Public Health Sciences, Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
¹³ Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
¹⁴ Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Abstract

The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women's Interagency HIV Study (2004-2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

Keywords: HIV; atherosclerosis; cardiovascular disease; menopause.

MeSH terms

Atherosclerosis*
Carotid Intima-Media Thickness
Female
HIV Infections* / complications
Humans
Menopause
Risk Factors

Abstract

MeSH terms

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