Rhodium-Catalyzed Asymmetric Functionalization of Quinoxalinium Salts

Org Lett. 2023 Dec 22;25(50):8987-8991. doi: 10.1021/acs.orglett.3c03555. Epub 2023 Dec 7.

Abstract

We report a rhodium-catalyzed asymmetric addition of aryl and alkenyl boronic acids to quinoxalinium salts that generates dihydroquinoxalines with high enantioselectivity. Functionalization of the reaction products, dihydroquinoxaline, allows the preparation of tetrahydroquinoxalines with various substitution patterns.