Midnolin-proteasome pathway for protein degradation

Wei-Lin Jin

doi:10.1002/mco2.450

Midnolin-proteasome pathway for protein degradation

MedComm (2020). 2023 Dec 10;4(6):e450. doi: 10.1002/mco2.450. eCollection 2023 Dec.

Author

Wei-Lin Jin¹

Affiliation

¹ Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University Lanzhou China.

Abstract

Overexpression of immediate-early genes (IEGs) has been linked to was associated with cancer progression and prognosis. In a recent study, Gu et al. reported the midnolin-proteasome pathway, a novel ubiquitin-independent proteasomal degradation. 1 The study provided the mechanism of rapid degradation for nuclear proteins with high unsteadiness. Targeting the midnolin-proteasome pathway might be beneficial for cancer therapy.