High BRCA1 expression is an independent prognostic biomarker in LUAD and correlates with immune infiltration

Fengzhu Guo; Cong Li; Shuning Liu; Zhijun Li; Jingtong Zhai; Zhiwu Wang; Binghe Xu

doi:10.1002/cai2.65

High BRCA1 expression is an independent prognostic biomarker in LUAD and correlates with immune infiltration

Cancer Innov. 2023 Apr 13;2(2):91-95. doi: 10.1002/cai2.65. eCollection 2023 Apr.

Authors

Fengzhu Guo^{1

2}, Cong Li¹, Shuning Liu¹, Zhijun Li¹, Jingtong Zhai¹, Zhiwu Wang³, Binghe Xu¹

Affiliations

¹ Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
² Department of Medical Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China.
³ Department of Chemoradiotherapy Tangshan People's Hospital Tangshan China.

Abstract

Lung adenocarcinoma (LUAD) patients with elevated breast cancer susceptibility gene 1 (BRCA1) expression had markedly worse overall survival and progression-free survival compared to those with reduced BRCA1 levels. In contrast, BRCA1 expression did not correlate with survival outcomes in squamous cell carcinoma patients. The overexpression of BRCA1 was an independent risk factor for LUAD and was indicative of an immune-suppressive tumor microenvironment.

Keywords: bioinformatics analysis; lung adenocarcinoma; meta‐analysis; non‐small‐cell lung cancer; prognosis.