Cytotoxic Th1 cells mushroom after fungal exposures in Crohn's disease

Martin Stražar; Ramnik J Xavier

doi:10.1016/j.immuni.2023.11.012

Cytotoxic Th1 cells mushroom after fungal exposures in Crohn's disease

Immunity. 2023 Dec 12;56(12):2679-2681. doi: 10.1016/j.immuni.2023.11.012.

Authors

Martin Stražar¹, Ramnik J Xavier²

Affiliations

¹ The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: mstrazar@broadinstitute.org.
² The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: xavier@molbio.mgh.harvard.edu.

PMID: 38091949
DOI: 10.1016/j.immuni.2023.11.012

Abstract

Fungi are consistently enriched in inflamed intestines, with elusive effects on host immunity. In a recent issue of Nature Medicine, Martini et al. identify a subset of Th1 cells able to lyse the epithelium, enriched in Crohn's disease patient samples after fungal exposure.

MeSH terms

Agaricales*
Crohn Disease*
Humans
Intestines / microbiology
Th1 Cells