Successful Management of Fetal Torsades de Pointes and Long QT Syndrome by a Cardio-Obstetrical Team

Manesha Putra; Yee Ming Lee; Emily Bucholz; Emma L Ross; Henry Galan; Nicholas Behrendt; Kestutis Micke; Franklin S Chow; Michael V Zaretsky; Bettina F Cuneo

doi:10.1016/j.jaccas.2023.102110

Successful Management of Fetal Torsades de Pointes and Long QT Syndrome by a Cardio-Obstetrical Team

JACC Case Rep. 2023 Dec 6:27:102110. doi: 10.1016/j.jaccas.2023.102110.

Authors

Manesha Putra^{1

2

3}, Yee Ming Lee⁴, Emily Bucholz⁵, Emma L Ross⁶, Henry Galan^{1

2}, Nicholas Behrendt^{1

2}, Kestutis Micke^{1

2}, Franklin S Chow^{1

2}, Michael V Zaretsky^{1

2}, Bettina F Cuneo^{1

5}

Affiliations

¹ Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, Colorado, USA.
² Section of Maternal-Fetal Medicine University of Colorado School of Medicine, Aurora, Colorado, USA.
³ Section of Genetics, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁴ Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA.
⁵ Division of Cardiology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁶ Department of Pharmacy, Children's Hospital Colorado, Aurora, Colorado, USA.

Abstract

A 32-week fetus with tachycardia and bradycardia, diagnosed with torsades de pointes, atrioventricular block, and sinus bradycardia due to a de novo KCNH2 mutation was successfully managed by a cardio-obstetrical team. Maternal/fetal pharmacogenomic testing resulted in appropriate drug dosing without toxicity and delivery of a term infant in sinus rhythm.

Keywords: fetal arrhythmia; genetic testing; long QT syndrome; pharmacogenomics.

Publication types

Case Reports