Chimeric antigen receptor Treg therapy in transplantation

Abstract

In the quest for more precise and effective organ transplantation therapies, chimeric antigen receptor (CAR) regulatory T cell (T_reg) therapies represent a potential cutting-edge advance. This review comprehensively analyses CAR T_regs and how they may address important drawbacks of polyclonal T_regs and conventional immunosuppressants. We examine a growing body of preclinical findings of CAR T_reg therapy in transplantation, discuss CAR T_reg design specifics, and explore established and attractive new targets in transplantation. In addition, we explore present impediments where future studies will be necessary to determine the efficacy of CAR T_regs in reshaping alloimmune responses and transplant microenvironments to reduce reliance on chemical immunosuppressants. Overall, ongoing studies and trials are crucial for understanding the full scope of CAR T_reg therapy in transplantation.

Keywords: antigen-specific immunotherapy; chimeric antigen receptors; regulatory T cells; transplant tolerance.