Novel vic-dioximes: synthesis, structure characterization, and antimicrobial activity evaluation

Dumitru Ureche; Ion Bulhac; Alexandru Ciocarlan; Daniel Roshca; Lucian Lupascu; Paulina Bourosh

doi:10.3906/kim-2104-24

Novel vic-dioximes: synthesis, structure characterization, and antimicrobial activity evaluation

Turk J Chem. 2021 Aug 15;45(6):1873-1881. doi: 10.3906/kim-2104-24. eCollection 2021.

Authors

Dumitru Ureche¹, Ion Bulhac¹, Alexandru Ciocarlan¹, Daniel Roshca¹, Lucian Lupascu¹, Paulina Bourosh^{1

2}

Affiliations

¹ Institute of Chemistry, Chisinau, Republic of Moldova.
² Institute of Applied Physics, Chisinau, Republic of Moldova.

Abstract

The vic-dioximes are compounds with various industrial uses and scientific applications. Many coordination compounds have been synthesized based on vic-dioximes. This study presents the synthesis and full characterization of two vic-dioximes based on dichloroglyoxime, p-aminobenzoic acid, and p-aminotoluene. Their structures were proved by IR, ¹H, ¹³C and ¹⁵N NMR spectral analysis, and single crystal X-ray diffraction. One of the reported vic-dioximes, bis(di-p-aminotoluene)glyoxime mono-p-aminotoluene trihydrate showed good to moderate antimicrobial activity against both nonpathogenic gram-positive and gram-negative bacteria (Bacillus subtilis and Pseudomonas fluorescens), phytopathogenic (Xanthomonas campestris, Erwinia amylovora, E. carotovora) and the fungi (Candida utilis and Saccharomyces cerevisiae) at MIC - 70-150 μg/mL.

Keywords: X-ray diffraction; antibacterial activity; antifungal activity; spectral analysis; vic-dioxime.