Case Report: First case of HIV, hepatitis B, hepatitis C, and Vibrio vulnificus coinfection

Front Cell Infect Microbiol. 2023 Dec 11:13:1290636. doi: 10.3389/fcimb.2023.1290636. eCollection 2023.

Abstract

Our patient, a 48-year-old man from Guangdong's coastal region, worked selling and processing oysters and other seafood. He started experiencing swelling and pain in his left knee on October 4, 2022, and they got worse over time. The findings of mNGS test showed Vibrio vulnificus infection. The patient had AIDS, hepatitis A and hepatitis B concurrently. He was admitted to the hospital's intensive care unit (ICU) for treatment as his symptoms worsened. We refrained from performing an amputation because the family members expressed a desire to keep the limb. The limb was managed with regular dressing changes, thorough debridement, wound closure, ongoing VSD drainage, and local antibiotic irrigation. The patient's organ function eventually returned to normal, and the systemic infection got better. On November 1, the wound's new granulation tissue had grown well and had gradually crept to cover 80% of the wound. The tissue's blood flow had also improved, indicating a trend of growth and healing.

Keywords: HIV; Vibrio vulnificus; hamster models; hepatitis B; hepatitis C.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coinfection* / complications
  • Coinfection* / diagnosis
  • HIV Infections* / complications
  • Hepatitis B*
  • Hepatitis C*
  • Humans
  • Male
  • Middle Aged
  • Vibrio Infections* / diagnosis
  • Vibrio Infections* / therapy
  • Vibrio vulnificus*

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by National key R&D projects (2022YFC2302701), Science and Technology Planning Project of Guangdong Province, China (2022B1111010004), Basic Research Program of Guangzhou Municipal Science and Technology Bureau (SL2023A03J01074).