Towards in vitro models for reducing or replacing the use of animals in drug testing

Affiliations

• ¹ Quantitative, Translational & ADME Sciences, AbbVie, North Chicago, IL, USA. david.stresser@abbvie.com.
• ² International Consortium for Innovation and Quality in Pharmaceutical Development (IQ), . david.stresser@abbvie.com.
• ³ IQ Microphysiological Systems Affiliate (IQ-), . david.stresser@abbvie.com.
• ⁴ International Consortium for Innovation and Quality in Pharmaceutical Development (IQ).
• ⁵ IQ Microphysiological Systems Affiliate (IQ-).
• ⁶ Drug Safety Research & Development, Pfizer, Inc., Groton, CT, USA.
• ⁷ Chemical and Preclinical Safety, Merck KGaA, Darmstadt, Germany.
• ⁸ Discovery Toxicology, Pharmaceutical Candidate Optimization, Bristol Myers Squibb, San Diego, CA, USA.
• ⁹ Investigative Toxicology and Pathology, AbbVie, North Chicago, IL, USA.
• ¹⁰ Global Animal Welfare, AbbVie, North Chicago, IL, USA.
• ¹¹ IQ 3Rs (Replacement, Reduction, Refinement) Translational and Predictive Sciences Leadership Group.
• ¹² Quantitative, Translational & ADME Sciences, AbbVie, North Chicago, IL, USA.
• ¹³ IQ Translational and ADME Sciences Leadership Group (TALG).
• ¹⁴ Clinical Pharmacology & Safety Sciences, AstraZeneca, Cambridge, UK.
• ¹⁵ Product Quality & Occupational Toxicology, Genentech, Inc., South San Francisco, CA, USA.
• ¹⁶ IQ DruSafe.
• ¹⁷ Safety Assessment, Genentech, Inc., South San Francisco, CA, USA.
• ¹⁸ UCB Pharma, Cambridge, MA, USA.
• ¹⁹ Investigative Toxicology, Genentech, Inc., South San Francisco, CA, USA.
• ²⁰ Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
• ²¹ Global Investigative Toxicology, Preclinical Safety, Sanofi, Cambridge, MA, USA.
• ²² Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer, Inc, Cambridge, MA, USA.
• ²³ Preclinical Safety, AbbVie, North Chicago, IL, USA.
• ²⁴ Discovery Biology, Incyte, Wilmington, DE, USA.
• ²⁵ Investigative Toxicology, Early Development, Alnylam Pharmaceuticals, Cambridge, MA, USA.
• ²⁶ Predictive Toxicology, Genentech, Inc., South San Francisco, CA, USA.
• ²⁷ Translational Safety & Bioanalytical Sciences, Amgen Research, Amgen Inc., South San Francisco, CA, USA.
• ²⁸ Laboratory Animal Resources, Incyte, Wilmington, DE, USA.
• ²⁹ Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA.
• ³⁰ Preclinical Safety Assessment, Vertex Pharmaceuticals, Inc, Boston, MA, USA.
• ³¹ International Consortium for Innovation and Quality in Pharmaceutical Development (IQ), . homan.kimberly@gene.com.
• ³² IQ Microphysiological Systems Affiliate (IQ-), . homan.kimberly@gene.com.
• ³³ Complex in vitro Systems Group, Genentech, Inc., South San Francisco, CA, USA. homan.kimberly@gene.com.