Mitochondrial transplantation: the advance to therapeutic application and molecular modulation

James D McCully; Pedro J Del Nido; Sitaram M Emani

doi:10.3389/fcvm.2023.1268814

Mitochondrial transplantation: the advance to therapeutic application and molecular modulation

Front Cardiovasc Med. 2023 Dec 15:10:1268814. doi: 10.3389/fcvm.2023.1268814. eCollection 2023.

Authors

James D McCully^{1

2}, Pedro J Del Nido^{1

2}, Sitaram M Emani^{1

2}

Affiliations

¹ Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, United States.
² Harvard Medical School, Boston, MA, United States.

Abstract

Mitochondrial transplantation provides a novel methodology for rescue of cell viability and cell function following ischemia-reperfusion injury and applications for other pathologies are expanding. In this review we present our methods and acquired data and evidence accumulated to support the use of mitochondrial transplantation.

Keywords: heart; mitochondria; mitochondrial transplantation; proteomics; transcriptomics.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article.