Exploring noncoding variants in genetic diseases: from detection to functional insights

J Genet Genomics. 2024 Feb;51(2):111-132. doi: 10.1016/j.jgg.2024.01.001. Epub 2024 Jan 4.

Abstract

Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies. The intricacies of noncoding regions introduce a multitude of challenges and research opportunities. In this review, we introduce a spectrum of noncoding variants involved in genetic diseases, along with research strategies and advanced technologies for their precise identification and in-depth understanding of the complexity of the noncoding genome. We will delve into the research challenges and propose potential solutions for unraveling the genetic basis of rare and complex diseases.

Keywords: Challenge; Genetic disease; Noncoding variation; Research approach.

Publication types

  • Review

MeSH terms

  • Genetic Predisposition to Disease / genetics
  • Genetic Variation* / genetics
  • Genome-Wide Association Study
  • Genomics*
  • Humans
  • Precision Medicine