Effects of in ovo injection of bacterial peptides and CpG-ODN on Salmonella enterica serovar Heidelberg infection in specific pathogen-free (SPF) chicks

Victória Veiga Alves; Letícia Cury Rocha Veloso Arantes; Dayse Helena Lages da Silva; Eric Santos Oliveira; Julia Figueiredo de Souza; Mailson Teixeira da Silva; Matheus Dias Araújo; Rodrigo Dias de Oliveira Carvalho; João Luís Reis Cunha; Leonardo José Camargos Lara; Roselene Ecco; Nelson Rodrigo da Silva Martins; Paul Andrew Barrow; Oliveiro Caetano de Freitas Neto

doi:10.1080/03079457.2024.2307567

Effects of in ovo injection of bacterial peptides and CpG-ODN on Salmonella enterica serovar Heidelberg infection in specific pathogen-free (SPF) chicks

Avian Pathol. 2024 Jun;53(3):182-193. doi: 10.1080/03079457.2024.2307567. Epub 2024 Feb 9.

Authors

Victória Veiga Alves¹, Letícia Cury Rocha Veloso Arantes¹, Dayse Helena Lages da Silva², Eric Santos Oliveira², Julia Figueiredo de Souza¹, Mailson Teixeira da Silva¹, Matheus Dias Araújo², Rodrigo Dias de Oliveira Carvalho³, João Luís Reis Cunha⁴, Leonardo José Camargos Lara⁵, Roselene Ecco², Nelson Rodrigo da Silva Martins¹, Paul Andrew Barrow⁶, Oliveiro Caetano de Freitas Neto¹

Affiliations

¹ Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
² Sector of Animal Pathology and MULTILAB, Department Veterinary Clinic and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
³ Pharmacy School, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
⁴ Department of Biology, University of York, Heslington, UK.
⁵ Department of Animal Science, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
⁶ School of Veterinary Medicine, University of Surrey, Guildford, UK.

PMID: 38240226
DOI: 10.1080/03079457.2024.2307567

Abstract

Peptides + CpG-ODN reduced SH in caeca at the first week post-infection.Administered formulations did not reduce SH-faecal excretion.Levels of intestinal IgA were similar between all groups.CpG-ODN improved some parameters associated with chick intestinal health.

Keywords: Poultry production; fowl paratyphoid; gut health; intestinal colonization; linear epitopes; protection.

MeSH terms

Animals
Chickens
Poultry Diseases* / microbiology
Poultry Diseases* / prevention & control
Salmonella Infections, Animal* / microbiology
Salmonella Infections, Animal* / prevention & control
Salmonella enterica*
Serogroup