Advanced considerations in survival analysis

Eur J Cardiothorac Surg. 2024 Feb 1;65(2):ezae020. doi: 10.1093/ejcts/ezae020.

Abstract

Investigation of survival during the follow-up period is common in cardiovascular research and has intrinsic issues that require precise knowledge, such as survival or censoring. Besides, as the follow-up period lengthens and events other than mortality are studied, the analysis becomes more complex, so Kaplan-Meier analyses or Cox models are not always sufficient. In this primer, we provide the reader with detailed information on the interpretation of the most common survival analyses and delve into methods to analyse competing risks or alternatives to the conventional methods when the proportional hazards assumption is not met.

Keywords: competing risks analysis; proportional hazards assumption; restricted mean survival time; survival analysis.

MeSH terms

  • Heart*
  • Humans
  • Kaplan-Meier Estimate
  • Proportional Hazards Models
  • Survival Analysis