Biomolecules of Muscle Fatigue in Metabolic Myopathies

Biomolecules. 2023 Dec 30;14(1):50. doi: 10.3390/biom14010050.

Abstract

Metabolic myopathies are a group of genetic disorders that affect the normal functioning of muscles due to abnormalities in metabolic pathways. These conditions result in impaired energy production and utilization within muscle cells, leading to limitations in muscle function with concomitant occurrence of related signs and symptoms, among which fatigue is one of the most frequently reported. Understanding the underlying molecular mechanisms of muscle fatigue in these conditions is challenging for the development of an effective diagnostic and prognostic approach to test targeted therapeutic interventions. This paper outlines the key biomolecules involved in muscle fatigue in metabolic myopathies, including energy substrates, enzymes, ion channels, and signaling molecules. Potential future research directions in this field are also discussed.

Keywords: biomolecules; metabolic myopathies; muscle fatigue.

Publication types

  • Review

MeSH terms

  • Humans
  • Metabolism, Inborn Errors*
  • Muscle Cells
  • Muscle Fatigue
  • Muscles
  • Muscular Diseases*

Grants and funding

This research received no external funding.