Case report: Occult Listeria monocytogenes invasion leading to prosthetic hip joint infection in a patient with rheumatoid arthritis taking tofacitinib

Chaowen Deng; Kelvin Hei-Yeung Chiu; Nan Lou; Fanfan Xing

doi:10.3389/fmed.2023.1322993

Case report: Occult Listeria monocytogenes invasion leading to prosthetic hip joint infection in a patient with rheumatoid arthritis taking tofacitinib

Front Med (Lausanne). 2024 Jan 9:10:1322993. doi: 10.3389/fmed.2023.1322993. eCollection 2023.

Authors

Chaowen Deng¹, Kelvin Hei-Yeung Chiu², Nan Lou³, Fanfan Xing¹

Affiliations

¹ Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
² Department of Microbiology, Queen Mary Hospital, Hong Kong, Hong Kong SAR, China.
³ Department of Orthopedics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.

Abstract

It has been suggested that targeted therapy may potentially increase the risk of listeriosis. However, no reported cases of Listeria monocytogenes prosthetic joint infection have been documented during Janus Kinase (JAK) pathway inhibitor use. Herein, we present a 70-year-old female with rheumatoid arthritis who had undergone bilateral hip joint replacement and subsequently developed Listeria monocytogenes prosthetic joint infection following tofacitinib therapy. We suggest that the use of tofacitinib may potentially heighten susceptibility to listeriosis in patients afflicted with rheumatoid arthritis.

Keywords: Listeria monocytogenes; case report; prosthetic joint infection; rheumatoid arthritis; tofacitinib.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was partly supported by Sanming Project of Medicine in Shenzhen (SZSM201911014) and the High Level-Hospital Program, Health Commission of Guangdong Province, China.