Objective: To analyze the nutritional status of progeria, and to provide reference for scientific nutritional management of progeria. Methods: This cross-sectional study included 15 children with progeria who were treated at Children's Hospital, Zhejiang University School of Medicine, between April 2022 and May 2023. Data of medical history, physical examination, laboratory tests, dietary survey and body composition were collected and analyzed. Results: Among 15 patients there were 7 males and 8 females, aged 7.8 (2.3, 10.8) years. Twelve of the 15 patients exhibited signs of malnutrition. A 24-hour dietary survey was carried out in 14 of them. The daily energy intake of 11 cases was below recommended levels. Carbohydrate intake was insufficient in 10 cases, protein intake was insufficient in 7 cases, and fat intake was insufficient in 12 cases. Deficiencies in calcium, magnesium, iron and zinc were noted in 13, 13, 9 and 10 cases, respectively. Body composition was determined by dual-energy X-ray absorptiometry in 8 cases, and the bone mineral density was below average in 5 of them. Conclusions: Malnutrition, characterized by reduced energy intake, micronutrient deficiencies, and alteration in body composition, is prevalent in children with progeria. Regular routine nutritional assessment and proper interventions may benefit their long-term health status.
目的： 分析早老症患儿的营养状况，为早老症患儿的规范化营养管理提供临床参考。 方法： 采用横断面调查，收集2022年4月至2023年5月就诊于浙江大学医学院附属儿童医院的15例早老症患儿的病例资料，总结分析其病史、体格检查、实验室检查、膳食调查及人体学成分等资料。 结果： 15例早老症患儿中男7例、女8例，年龄为7.8（2.3，10.8）岁，其中12例患儿存在营养不良。14例患儿行24 h膳食调查，11例患儿每日能量摄入量未达到参考摄入量。10例患儿碳水化合物摄入不足，7例患儿蛋白质摄入不足，12例患儿脂肪摄入不足。钙、镁、铁和锌摄入量不足分别为13、13、9和10例。8例患儿采用双能X线吸收测定法测定体成分，其中5例骨密度水平低下。 结论： 早老症患儿普遍存在营养不良，伴随脂肪丢失，肌肉量减少及骨密度低下等，能量及各类营养素摄入不足，需要进行长期连续性营养评估及营养干预。.