Cell death proteins in sepsis: key players and modern therapeutic approaches

Chloe S Yang; Craig M Coopersmith; John D Lyons

doi:10.3389/fimmu.2023.1347401

Cell death proteins in sepsis: key players and modern therapeutic approaches

Front Immunol. 2024 Jan 11:14:1347401. doi: 10.3389/fimmu.2023.1347401. eCollection 2023.

Authors

Chloe S Yang¹, Craig M Coopersmith^{1

2}, John D Lyons^{1

2}

Affiliations

¹ Department of Surgery, Emory University, Atlanta, GA, United States.
² Emory Critical Care Center, Emory University, Atlanta, GA, United States.

Abstract

Cell death proteins play a central role in host immune signaling during sepsis. These interconnected mechanisms trigger cell demise via apoptosis, necroptosis, and pyroptosis while also driving inflammatory signaling. Targeting cell death mediators with novel therapies may correct the dysregulated inflammation seen during sepsis and improve outcomes for septic patients.

Keywords: apoptosis; cell death; inflammation; necroptosis; pyroptosis; sepsis.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Apoptosis*
Cell Death
Humans
Inflammation
Pyroptosis
Sepsis* / metabolism

Abstract

Publication types

MeSH terms

Grants and funding