Prognostic significance of pan-immune-inflammation value (PIV) in nasopharyngeal carcinoma patients

Na Zhang; Tao Hou; Sujuan Zhang; Jie Ling; Shun Jiang; Yangchun Xie; Xianling Liu; Chunhong Hu; Yuhua Feng

doi:10.1016/j.heliyon.2024.e24804

Prognostic significance of pan-immune-inflammation value (PIV) in nasopharyngeal carcinoma patients

Heliyon. 2024 Jan 19;10(2):e24804. doi: 10.1016/j.heliyon.2024.e24804. eCollection 2024 Jan 30.

Authors

Na Zhang¹, Tao Hou², Sujuan Zhang², Jie Ling², Shun Jiang², Yangchun Xie², Xianling Liu², Chunhong Hu², Yuhua Feng²

Affiliations

¹ Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Abstract

Background: Blood-based immune-inflammation indexes have been widely used to predict survival in a variety of cancers. In this research, we seeked to evaluate a novel immune-inflammation marker, named the pan-immune-inflammation value (PIV), in patients with nasopharyngeal carcinoma (NPC) undergoing definitive radiotherapy.

Methods: A group of 377 patients with NPC was retrospectived analyzed. Clinical data and laboratory data were collected. Receiver operating characteristic (ROC) curve analysis was performed in order to determine the optimal PIV cut-off value. Survival curves were estimated by Kaplan-Meier method, and prognostic variables were identified using a Cox regression model. Additionally, we developed a nomogram and assessed its acuracy using the concordance index (C-index) and a calibration curve.

Results: The optimal PIV cut-off value was 146.24 according to ROC analysis. High PIV was related to poorer Eastern Cooperative Oncology Group Performance Status (ECOG PS) score (p = 0.017), more advanced T (p＜0.001) and clinical stages (p = 0.024). In univariate analysis, older Age, poorer ECOG PS, higher Epstein-Barr virus DNA (EBV-DNA), advanced T, N and clinical stage, and higher PIV levels were related to patients' poorer overall survival (OS). Poorer ECOG PS, higher EBV-DNA, later T stage, later clinical stage, and higher PIV were associated with patients' poorer progression free survival (PFS). Male sex and later T stage were associated with patients' poorer locoregional recurrence free survival (LRRFS). Poorer ECOG PS, higher EBV-DNA, later T stage, later clinical stage, and higher PIV were associated with patients' poorer distant metastasis free survival (DMFS). Multivariate analysis demonstrated that PIV was an independent prognostic index for OS (HR 2.231, 95 % CI 1.241-4.011, P = 0.007), PFS (HR 1.664, 95 % CI 1.003-2.760, P = 0.049), and DMFS(HR 2.081, 95 % CI 1.071-4.044, P = 0.031). Nomogram C-indexes for the nomogram of OS were 0.684, and PFS were 0.62, respectively. Survival predictions and actual survival were consistent according to the calibration curve.

Conclusions: Pre-treatment PIV is a promising biomarker for predicting survival in patients with NPC.

Keywords: Nasopharyngeal carcinoma; Nomogram; Pan-immune-inflammation value; Prognosis.