Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer

Charlotte Lafont; Elena Paillaud; Chloe Bertolus; Melany Baron; Philippe Caillet; Eric Bouvard; Marie Laurent; Didier Salvan; Laurence Chaumette; Laure de Decker; Benoit Piot; Beatrix Barry; Agathe Raynaud-Simon; Elisabeth Sauvaget; Aurélien Minard; Amélie Anota; Henri Panjo; Lydia Brugel; Florence Canouï-Poitrine

doi:10.1093/jnci/djae027

Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer

J Natl Cancer Inst. 2024 May 8;116(5):758-763. doi: 10.1093/jnci/djae027.

Authors

Charlotte Lafont^{1

2}, Elena Paillaud^{1

3}, Chloe Bertolus⁴, Melany Baron⁵, Philippe Caillet^{1

3}, Eric Bouvard⁶, Marie Laurent^{1

7}, Didier Salvan⁸, Laurence Chaumette⁹, Laure de Decker¹⁰, Benoit Piot¹¹, Beatrix Barry¹², Agathe Raynaud-Simon¹³, Elisabeth Sauvaget¹⁴, Aurélien Minard¹⁵, Amélie Anota^{16

17}, Henri Panjo¹⁸, Lydia Brugel¹⁹, Florence Canouï-Poitrine^{1

2}

Affiliations

¹ Univ Paris Est Creteil, INSERM, IMRB, Creteil, France.
² Service de Santé Publique, AP-HP, Hôpital Henri-Mondor, Creteil, France.
³ Département de Gériatrie, AP-HP, Paris Cancer Institute CARPEM, Hôpital Européen Georges Pompidou, Paris, France.
⁴ Service de Chirurgie Maxillo-Faciale, AP-HP, Sorbonne Université, Hôpital Pitié Salpêtrière, Paris, France.
⁵ Service de Soins de Suites et de Réadaptation Gériatrique, AP-HP, Sorbonne Université, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Ivry sur Seine, France.
⁶ Service de Gériatrie, AP-HP, Hôpital Tenon, Paris, France.
⁷ Département de Gériatrie, AP-HP, Hôpital Henri-Mondor, Créteil, France.
⁸ Service ORL et Cervico-Facial, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
⁹ Service de Court Sejour Gériatrique, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
¹⁰ Service de Gériatrie, Centre Hospitalier Universitaire de Nantes, Nantes, France.
¹¹ Service de Chirurgie Maxillo-Faciale et Stomatologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.
¹² Service ORL et Chirurgie Cervico-Faciale, AP-HP, Université de Paris, Hôpital Bichat, Paris, France.
¹³ Service de Gériatrie, AP-HP, Université de Paris, Hôpital Bichat, Paris, France.
¹⁴ Service ORL et Chirurgie Cervico-Faciale, Groupe Hospitalier Paris-Saint Joseph, Paris, France.
¹⁵ Service de Gériatrie, Hôpital Léopold Bellan, Paris, France.
¹⁶ Clinical Research and Innovation Department and Department of Human and Social Sciences, Centre Léon Bérard, Lyon, France.
¹⁷ French National Platform Quality of Life and Cancer, Lyon, France.
¹⁸ Université Paris-Saclay, UVSQ, Inserm, CESP, Villejuif, France.
¹⁹ Service d'ORL et Chirurgie Cervico-Faciale, Centre Hospitalier Intercommunal de Créteil, Créteil, France.

PMID: 38335935
DOI: 10.1093/jnci/djae027

Abstract

Due to the location and toxicity of treatments, head and neck cancer (HNC) has a major impact on quality of life (QoL). Objective: to assess the effects of geriatric-assessment (GA)-driven interventions on QoL over 2 years in older adults with HNC.EGeSOR was a randomized study of HNC patients aged ≥65, receiving a pretreatment GA, a geriatric intervention and follow-up (intervention) or standard of care (control). The primary endpoint was QoL score using the European Organisation for Research and Treatment of Cancer's (EORTC QLQ-C30) and HNC (QLQ-HN35) QoL questionnaires over 24 months.In total, 475 patients were included (median age: 75.3; women: 31%; oral cancer: 44%). QoL scores improved over 24 months with various trajectories, without significant differences between the groups. A total of 74% of patients (interventional group) did not receive the complete intervention. Cancer characteristics, functional status, and risk of frailty were associated with change in the Global Health Status QoL score.There is a need to develop an alternative model of implementation such as patient-centered health-care pathways.

Trial registration: NCT02025062.

Publication types

Research Support, Non-U.S. Gov't
Randomized Controlled Trial

MeSH terms

Aged
Aged, 80 and over
Female
Frailty / epidemiology
Geriatric Assessment*
Head and Neck Neoplasms* / psychology
Head and Neck Neoplasms* / therapy
Humans
Male
Middle Aged
Quality of Life*
Surveys and Questionnaires

Associated data

ClinicalTrials.gov/NCT02025062

Abstract

Publication types

MeSH terms

Associated data

Grants and funding