Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery

Hannah G McDonald; Daniel M Kerekes; Joseph Kim; Sajid A Khan

doi:10.1016/j.soc.2023.12.007

Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery

Surg Oncol Clin N Am. 2024 Apr;33(2):321-341. doi: 10.1016/j.soc.2023.12.007. Epub 2024 Jan 9.

Authors

Hannah G McDonald¹, Daniel M Kerekes², Joseph Kim¹, Sajid A Khan³

Affiliations

¹ Department of General Surgery, Division of Surgical Oncology, The University of Kentucky, 800 Rose Street, Lexington, KY 40508, USA.
² Department of General Surgery, Division of Surgical Oncology, Yale University, 15 York Street, New Haven, CT 06510, USA.
³ Department of Surgery, Yale University, 15 York Street, New Haven, CT 06510, USA. Electronic address: Sajid.Khan@yale.edu.

PMID: 38401913
DOI: 10.1016/j.soc.2023.12.007

Abstract

Precision medicine is used to treat gastrointestinal malignancies including esophageal, gastric, small bowel, colorectal, and pancreatic cancers. Cutting-edge assays to detect and treat these cancers are active areas of research and will soon become standard of care. Colorectal cancer is a prime example of precision oncology as disease site is no longer the final determinate of treatment. Here, the authors describe how leveraging an understanding of tumor biology translates to individualized patient care using evidence-based practices.

Keywords: GI malignancies; Molecular medicine; Multiomics; Precision oncology; Targeted therapies.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / surgery
Gastrointestinal Neoplasms* / pathology
Gastrointestinal Neoplasms* / surgery
Humans
Medical Oncology
Pancreatic Neoplasms*
Precision Medicine