Efficacy of dalfampridine in neuromyelitis optica spectrum disorder: A pilot study

Mult Scler J Exp Transl Clin. 2024 Feb 29;10(1):20552173241233952. doi: 10.1177/20552173241233952. eCollection 2024 Jan-Mar.

Abstract

Objective: To assess the efficacy of dalfampridine in patients with neuromyelitis optica spectrum disorder.

Methods: We included 15 consecutive patients, who were started on a treatment of dalfampridine 10 mg twice daily for 2 weeks. Efficacy assessment was based on walking ability improvement using Timed-25-Foot Walk and 12-item Multiple Sclerosis Walking Scale tests.

Results: The mean Timed-25-Foot Walk score was reduced from 14.8 (±2.4) to 11.3 (±1.9) seconds (p = 0.01). The mean score on the 12-item Multiple Sclerosis Walking Scale was reduced from 41.2 (±3.5) to 31.4 (±3.2) (p = 0.004).

Conclusion: Dalfampridine seems to be useful for symptomatic treatment of walking impairment in neuromyelitis optica spectrum disorder.

Keywords: Fampridine; neuromyelitis optica; neuromyelitis optica spectrum disorder.