Clinical outcomes of outpatient thyroidectomy: A systematic review and single-arm meta-analysis

Hayato Nakanishi; Rongzhi Wang; Shahid Miangul; Grace E Kim; Omotayo A Segun-Omosehin; Natalie E Bourdakos; Christian A Than; Benjamin E Johnson; Herbert Chen; Andrea Gillis

doi:10.1016/j.amjsurg.2024.02.037

Clinical outcomes of outpatient thyroidectomy: A systematic review and single-arm meta-analysis

Am J Surg. 2024 Oct:236:115694. doi: 10.1016/j.amjsurg.2024.02.037. Epub 2024 Feb 27.

Affiliations

¹ St George's University of London, London, SW17 0RE, UK; University of Nicosia Medical School, University of Nicosia, 2417, Nicosia, Cyprus.
² Department of Surgery, University of Alabama at Birmingham. Birmingham, AL, USA.
³ Division of Emergency Medicine, NorthShore University Health System, Chicago, IL, USA.
⁴ St George's University of London, London, SW17 0RE, UK; University of Nicosia Medical School, University of Nicosia, 2417, Nicosia, Cyprus; School of Biomedical Sciences, The University of Queensland, St Lucia, 4072, Australia.
⁵ Division of Surgery, NorthShore University Health System, Chicago, IL, USA.
⁶ Department of Surgery, University of Alabama at Birmingham. Birmingham, AL, USA. Electronic address: agillis@uabmc.edu.

PMID: 38443270
DOI: 10.1016/j.amjsurg.2024.02.037

Abstract

Background: The aim of this meta-analysis is to investigate the safety of outpatient thyroidectomy based on 24-h and same-day discharge criteria.

Methods: CENTRAL, Embase, PubMed, and Scopus were searched. A meta-analysis of selected studies was performed. The review was registered prospectively with PROSPERO (CRD42022361134).

Results: Thirty-one studies met the eligibility criteria, with a total of 74328 patients undergoing thyroidectomy in an outpatient setting based on 24-h discharge criteria. Overall postoperative complications after outpatient thyroidectomies were 5.7% (95%CI: 0.049-0.065; I2 = 97.3%), consisting of hematoma (0.4%; 95%CI: 0.003-0.005; I2 = 83.4%), recurrent laryngeal nerve injury (0.4%; 95%CI: 0.003-0.006; I2 = 93.5%), and hypocalcemia (1.6%; 95%CI: 0.012-0.019; I2 = 93.7%). The rate of readmission was 1.1% (95%CI: 0.007-0.015; I2 = 95.4%). Results were similar for same-day criteria.

Conclusions: Our analysis demonstrated that outpatient thyroidectomy is a safe procedure in the management of thyroid disease for selected patients.

Keywords: Complications; Endocrine; Hematoma; Meta-analysis; Outpatient; Thyroidectomy.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Ambulatory Surgical Procedures* / adverse effects
Ambulatory Surgical Procedures* / statistics & numerical data
Humans
Postoperative Complications* / epidemiology
Thyroidectomy* / adverse effects
Thyroidectomy* / methods
Thyroidectomy* / statistics & numerical data
Treatment Outcome