Uses and limitations of small-volume biopsies for the diagnosis of lymphoma

Cytopathology. 2024 Jul;35(4):454-463. doi: 10.1111/cyt.13372. Epub 2024 Mar 10.

Abstract

Although surgical biopsy remains the gold standard for the diagnosis of lymphoma, small-volume biopsies including fine-needle aspiration and core needle biopsy are increasingly being used as a first line diagnostic tool. Small-volume biopsies are safe, rapid and cost effective; however, diagnostic utility varies by lymphoma subtype. It is important for pathologists and clinicians to recognize both the strengths and limitations of such biopsies.

Keywords: core needle biopsy; fine‐needle aspiration; lymphoma; small‐volume biopsy; surgical biopsy.

Publication types

  • Review

MeSH terms

  • Biopsy, Fine-Needle / methods
  • Biopsy, Large-Core Needle / methods
  • Humans
  • Lymphoma* / diagnosis
  • Lymphoma* / pathology