Phosphoinositide-3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations

Anurag Bhalla; Katherine Radford; Kiho Son; Kayla Zhang; Chynna Huang; Melanie Kjarsgaard; Nicola LaVigne; Zachary Brautigam; Sarah Svenningsen; Guillaume Paré; Manali Mukherjee; Parameswaran Nair

doi:10.1111/cea.14471

Phosphoinositide-3 kinase activity in severe eosinophilic asthma with recurrent airway infections and neutrophilic exacerbations

Clin Exp Allergy. 2024 Jun;54(6):428-431. doi: 10.1111/cea.14471. Epub 2024 Mar 11.

Affiliations

¹ Division of Respirology, Western University, London, Ontario, Canada.
² Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
³ Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
⁴ Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

PMID: 38467536
DOI: 10.1111/cea.14471

No abstract available

Keywords: glucocorticosteroid subsensitivity; histone deacetylase; macrophage receptor with collagenous structure; phosphoinositide‐3 kinase; severe asthma.

Publication types

Letter

MeSH terms

Adult
Asthma* / drug therapy
Asthma* / immunology
Disease Progression
Eosinophils / immunology
Female
Humans
Male
Middle Aged
Neutrophils* / immunology
Neutrophils* / metabolism
Phosphatidylinositol 3-Kinases / metabolism
Recurrence
Respiratory Tract Infections* / immunology
Severity of Illness Index

Substances

Phosphatidylinositol 3-Kinases